To prevent blisters, minimize friction to your skin. Wear shoes that fit properly. If you have peripheral neuropathy that causes tingling or loss of feeling in your feet, be certain that your podiatrist evaluates your shoe wear to be certain of its fit. Be certain that the shoes you wear are appropriate for your level of activity. Also, evaluate your sock selection. Layering socks can minimize friction, however, you need to make sure that there are no wrinkles or creases in the layers, or you risk forming a blister on the sole of your foot. Change your socks frequently if your feet sweat a lot.
Another way of preventing friction is to use products that dry the feet, such as baby powder, before applying socks. A thin layer of petroleum jelly may also help reduce friction. Be sure to apply petroleum jelly sparingly, and avoid applying between the toes. To prevent blisters on the palms, use gloves to decrease friction, and be sure to keep hands dry.