The best way to prevent Herpes Simplex infection is to avoid contact with someone who has it. Avoid touching or kissing active blisters, as they can be spread from the blister to the eyes or genitals, or from person to person. Frequent hand washing is an important way to limit transmission of the virus.Over-the-counter creams or ointments are available to ease the discomfort. Physicians may prescribe anti-viral medications that may speed the healing process, if used at the onset of the blister. Some people start taking vitamin C when they feel a cold sore beginning; it has not been proven that this is effective, but advocates feel this shortens the cold core cycle.